Top 10 Major Area Employers – Cuero
(As of February 2017)
| 1. | Cuero Regional Hospital – Healthcare | 436 |
| 2. | Cuero Independent School District – School District | 368 |
| 3. | Texas Dept. of Criminal Justice – Correctional Facility | 348 |
| 4. | DeWitt County – Government | 154 |
| 5. | H-E-B – Retail Grocery | 120 |
| 6. | City of Cuero – Government | 110 |
| 7. | Cuero Nursing and Rehab Center – Health Care | 109 |
| 8. | Walmart – Retail Store | 91* |
| 9. | Pioneer Natural Resources – Petroleum & Natural Gas | 89 |
| 10. | McMahan Welding – Industrial | 62 |
*(As of August 2016)